30CrNi3MoV钢的热变形行为及热加工图

采用Gleeble-3500热模拟试验机对30CrNi3MoV钢进行单向热压缩试验,研究了其在变形温度950~1150 ℃、应变速率0.01~10 s^-1的热变形行为,构建了应变补偿型流变应力本构方程,并绘制出该钢的热加工图。结果表明,30CrNi3MoV钢真应力-真应变曲线有3种不同特征:高温小应变速率时,表现为典型的动态再结晶过程;低温小应变速率时,曲线为动态回复特征;应变速率较大时,应力随应变的增大而增大,无明显的峰值应力。采用5次多项式拟合构建的应变耦合流变应力本构方程具有高的精确度,采用该方程获得的预测值与试验值的平均相对误差为3.2%,相关性系数R值为0.993。从热加工图中得到试验钢最佳的热加工工艺参数范围是:变形温度为1020~1150 ℃、应变速率为0.03~0.35 s^-1。     

Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer

The RNA methylase METTL3 catalyzes the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to the N⁶ atom of adenine. We have screened a library of 4000 analogues and derivatives of the adenosine moiety of SAM by high-throughput docking into METTL3. Two series of adenine derivatives were identified in silico, and the binding mode of six of the predicted inhibitors was validated by protein crystallography. Two compounds, one for each series, show good ligand efficiency. We propose a route for their further development into potent and selective inhibitors of METTL3.     

3D seismic and formation micro-imager (FMI) integrated study to delineate depositional pattern of Abu Madi (Upper Miocene) clastic reservoir rocks in El-Wastani gas field,onshore Nile Delta,Egypt

Ten wells (EW-4, EW-5, EW-6, EW-7, EW-8, EW-9, EW-10, EW-12, EW-13 and EW-15) were interpreted using the composite well logs, data of core analysis, gamma-ray logs, formation micro-imager logs (FMI), and 3D seismic data in SEGY format to understand the stratigraphy of the onshore, Nile Delta, Egypt.The amplitude analysis of 3-D seismic horizon slice of Lower Abu Madi rock unit together with the lithostratigraphic correlation through the study area depending on the gamma-ray log “HSGR” (left to right increasing), and the identification of type of bed geometry, nature of bed contacts, type of the sedimentary structures and the dominant formative paleocurrents by using some available borehole micro-resistivity images (FMI) and core photos. All of these techniques are used together to define the different depositional facies and depositional environment of the Messinian clastics (Lower Abu Madi rock unit), which is considered to be the main reservoir in the El-Wastani gas field, onshore Nile Delta, Egypt.The present study of depositional pattern of the Upper Miocene clastics reservoir (Lower Abu Madi rock unit) revealed that it is represented by high sinuous meandering channels or paleo-valley and three types of fluvial facies were defined; channel fill, channel margin, and floodplain basin.     

Experimental investigation and numerical simulation analysis of sintered micro-fluidic devices

ABSTRACT

This study investigates the use of numerical simulations to describe the solid-state diffusion of a sintering stage during a metal injection moulding process for micro-fluidic components with 316L stainless steel powders. Finite element (FE) analysis based on a thermo-elasto-viscoplastic model was conducted to describe the densification process of a stainless steel porous component during solid-state sintering. The numerical analyses, which were performed on a 3D micro-structured component with various powder volume loadings to take into account the thermal debinding effect to propose a full debinding sintering simulation, demonstrated that the FE simulation results are in agreement with the experimental ones.     

基于局部特征的青年女性腿部形态分类

为提高女性裤装的合体性与舒适性,采用三维测量法、图像测量法及手工测量法相结合的方式,对236名18~25岁的青年女性腿部形态进行测量,获取20个相关特征变量;通过主成分因子分析得到影响腿部形态的主要特征因子,通过聚类分析得到青年女性腿部形态的分类结果;最后结合膝曲角的正负归纳出各类腿部形态的辨别规则并进行辨别验证。研究得出:影响腿部形态的主要特征因子有水平围度因子、长度因子、小腿围度差因子、腿部曲度因子、腿部轮廓因子和大腿围度差因子;人体腿部形态可分成圆体型、稍扁体型和扁体型3类;以大腿宽厚比、大腿根围膝围比、大小腿长比及膝曲角4个变量建立腿部形态分类规则。     

Effects of polysaccharides and polyphenolics fractions of Zijuan tea (Camellia sinensis var. kitamura) on α‐glucosidase activity and blood glucose level and glucose tolerance of hyperglycaemic mice

The effects of polysaccharides, theaflavins, thearubigins and theabrownin fractions of Zijuan tea on α‐glucosidase and blood glucose level and intolerance of hyperglycaemic mice were evaluated. The polysaccharides or theaflavins fraction exhibited greater inhibition rate of α‐glucosidase than acarbose positive control, thearubigins fraction or theabrownin fraction. The four fractions were delivered to the treatment mice through oval gavage each day for 15 days. The mice in polysaccharides and theaflavins high‐ and low‐dose and theabrownin high‐dose treatments significantly lowered their blood glucose levels while all the treatment mice gained body weight. The mice in polysaccharides, theaflavins and theabrownin high‐ and low‐dose treatments had greater glucose tolerance as well. Thus, the theaflavins and polysaccharides fractions of Zijuan tea effectively moderated the complications of hyperglycaemic mice. The lower effectiveness of thearubigins and theabrownin fractions may be caused by the highly polymerised polyphenolics which decreased their accessibility to α‐glucosidase and digestibility in mice.     

Physical and thermal properties of l‐lactide/ϵ‐caprolactone copolymers: the role of microstructural design

Understanding the underlying role of microstructural design in polymers allows for the manipulation and control of properties for a wide range of specific applications. As such, this work focuses on the study of microstructure–property relationships in l‐ lactide/?‐caprolactone (LL/CL) copolymers. One‐step and two‐step bulk ring‐opening polymerization (ROP) procedures were employed to synthesize LL/CL copolymers of various compositions and chain microstructures. In the one‐step procedure, LL and CL were simultaneously copolymerized to yield P(LL‐stat‐CL) statistical copolymers. In the two‐step procedure, poly(l‐ lactide) (PLL) and poly(?‐caprolactone) (PCL) prepolymers were synthesized in the first step before CL and LL respectively were added in the second step to yield P[LL‐b‐(CL‐stat‐LL)‐b‐LL] and P[CL‐b‐(LL‐stat‐CL)‐b‐CL] block copolymers as the final products. The findings reveal that, in addition to the copolymerization procedure employed, the length and type of the prepolymer play important roles in determining the chain microstructure and thereby the overall properties of the final copolymer. Moreover, control over the degree of crystallinity and the type of crystalline domains, which is controlled during the polymer chemistry process, heavily influences the physical and mechanical properties of the final polymer. In summary, this work describes an interesting approach to the microstructural design of biodegradable copolymers of LL and CL for potential use in biomedical applications. © 2019 Society of Chemical Industry     

Doping manganese into CsPb(Cl/Br)3 quantum dots glasses: Dual-color emission and super thermal stability

CsPbX₃ (X = Cl, Br, I) perovskite quantum dots (QDs) represent bright and tunable photoluminescence, it is regrettable that the air instability and poor water resistant properties prevent their application in optoelectronic devices. At the same time, the toxicity of lead is also a major factor restricting its development. As a consequence, we demonstrate the partial replacement of Pb with Mn through conventional melt-quenching and heat-treatment method preparation of Mn-doped CsPb(Cl/Br)₃ QD glass. Mn-doped CsPb(Cl/Br)₃ QD glass exhibits high luminescent intensity like QDs. It is important that Mn-doped CsPb(Cl/Br)₃ QD glass with Dual-Color maintained the same lattice structure like Mn-doped CsPb(Cl/Br)₃ QDs, and highly homogeneous spectral characteristics of Mn luminescence. The intensity and position of this Mn-related emission are also tunable by altering the experimental parameters, such as the Pb-to-Mn feed ratio, annealing temperature. More importantly, the as-prepared orange Mn-doped CsPb(Cl/Br)₃ QD glass was employed to fabricate white LEDs combined with a commercial Ce³⁺:Y₃Al₅O₁₂ phosphor-in-glass (Ce-PiG) on top of a InGaN blue chip. And the constructed WLEDs generate a warm white with an optimal luminous efficacy (LE) of 67.00 lm/W, a high CRI of 81.4, and a low CCT of 4902 K.